2016; 01(01): 006-011 mds/16/1620/gmj

Original Research Article

Do Women Undergoing Intrauterine Insemination Procedures Critically Require Luteal Phase Support? : A Retrospective Case-Control Study

KARACA Nilay, M.D. 1*, OZCAN Pinar, M.D. 1, KOVALAK E. Evrim, M.D. 1, YILMAZ Rabiye M.D.1, ATES Seda, M.D. 1, BATMAZ Gonca, M. D. 1, USTA T. Abdullah, M.D.2
1* Bezmialem University Department of Obstetrics and Gynecology, Istanbul,Turkey.
2Bagcilar Training and Research Hospital, Bagcilar, Istanbul, Turkey.

Correspondence to
KARACA Nilay, M.D/ Bezmialem University Department of Obstetrics and Gynecology, Istanbul,Turkey.

First Published Online 30 November 2016


Background: To evaluate the progesterone for luteal phase support in improving clinical pregnancy rates (PRs) in intrauterine insemination (IUI) with ovarian stimulation (OS) and to investigate other factors that may affect PRs. Methods: A total of 579 women underwent OS with gonadotropins. Of 579 patients, 284 cycles received luteal phase support in the form of vaginal micronized progesterone capsules, while 295 cycles did not receive luteal support. Analyses were performed using the statistical package for the Social Sciences, version 21 (SPSS, Chicago, IL).
Results: Of IUI cycles, 132 (22.7%) resulted in a clinical pregnancy. In women who conceived, there was no significant difference between any progesterone group (n=59) (%20) and progesterone group (n=73) (%25) in terms of clinical PRs (p=0.055). Clinical PRs were similar to in women underwent OS with rFSH (p=0.41) or hMG (p=0.06) in progesterone group and no progesterone group. However, the pregnancy rates were influenced by age (p=0.03), FSH levels on cycle day 3 (0.02) and a number of dominant follicles (p=0.01). .
Conclusions: Our results did not support the efficacy of routine supplementation of the luteal phase with progesterone in IUI cycles, likely because the endocrine mechanisms normally regulating the luteal phase are not disturbed during IUI cycles with mild OS. On the other hand, there may be more important factors such as age, number of dominant follicles affecting to pregnancy rates.

Keywords: Pregnancy rates, Intrauterine insemination, Ovarian stimulation, Luteal support, Progesterone

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