2017; 02(01): 016-025 ort/16/1620/gmj

Original Article

Resistin, Leptin and Antioxidant Vitamins A and E Status in a Tunisian Group of Obese Men Diabetics

1National Institute of Public Health
2Faculty of Pharmacy of Monastir.
3Service "C" of Nutrition and Therapeutic Diet Diseases. National Institute of Nutrition.
4Laboratory of Clinical Biochemistry. National Institute of Nutrition.

Correspondence to
Fethi BEN SLAMA National Institute of Public Health

First Published Online 16 January 2017


Introduction: Our work is a comparative study that aims to evaluate vitamins A and E, leptin and Resistin serum levels in a population of obese diabetic males and to identify any correlations that may exist between these parameters.Materials and Methods: A measurement of vitamins A and E, leptin, Resistin, glucose, insulin and some lipid parameters serum levels was performed in 30 obese diabetic men free of all other metabolic and /or physical diseases with a mean age of (47, 97 ± 4.32) years old compared to 30 healthy subjects. Results: Our results showed a significant difference between the two groups as for the vitamins A and E, leptin and Resistin levels. Indeed, vitamin A level in our obese diabetic patients is (0,50 ± 0,46 mg/l) against (1,98 ± 0,97 mg/l) for the control group and vitamin E level is (7,92 ± 2,94 mg/l) against (12,21 ± 1,57 mg/l) for the control group. Moreover, leptin level (which is 18,22 ± 4,35 ng/ml) and Resistin level (which is 8,55 ± 2,86 ng/ml) of obese diabetic males are significantly higher than those observed for healthy individuals (respectively 4,51 ± 1,94 ng/ml and 3,72 ± 1,20 ng/ml).Correlations showed that there is a significant negative association between leptin and vitamin A (r = -0,58 ; p = 0,001) also leptin and vitamin E (r = -0,501; p = 0.005). As well, an inverse significant relationship was found between resistin and vitamin A (r = -0,42; p = 0,021) likewise Resistin and vitamin E (r = -0,534; p = 0,002). Discussion: Our results are consistent with those of several studies demonstrating a significant reduction in rates of vitamins A and E and a remarkable increase in leptin and resistin serum levels in obese diabetic subjects. This confirms the inverse relationship of vitamins A and E with leptin and Resistin. Other studies have reported contradictory results.Conclusion: The antioxidant status of the obese diabetic subject is altered and vitamins A and E rates are lowered. Given the inverse significant correlation with leptin and Resistin, vitamins A and E may exert a specific effect on the secretion and expression of these two adipokines.

Keywords: Obesity, Diabetes, Resistin, Leptin, BMI, Antioxidants

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