2016; 01(02): 012-016 prc/16/1620/gmj

Original Research Article

Small Cell Carcinoma of Prostate: A Case Report of a Patient With a Normal PSA and a Giant Prostate Volume

Alan Hasigov1, 2, 3 , Jean Paul Ndamba Engbang2, 3, 4 , Tamerlan Tlatov1, Aleksandre Ephiev1,3
1Republican Oncology Center, Vladikavkaz, Russia
2Republican Clinical Hospital, Vladikavkaz, Russia
3North-Ossetian State Medical Academy, Vladikavkaz, Russia
4Faculty of Medicine and Pharmaceutical Sciences, The University of Douala, Douala, Cameroon.

Correspondence to
Jean Paul Ndamba Engbang, Faculty of Medicine and Pharmaceutical Sciences, The University of Douala, BP 2701 Douala, Cameroon
E-mail: jean_pen@yahoo.ca, jpauleng@gmail.com

First Published Online 19 December 2016

ABSTRACT

Neuroendocrine differentiation (NED) in prostate cancer (PCa) implies the presence of a malignant neoplasm of the prostate with the neuroendocrine component. NED is a common feature of prostatic adenocarcinomas. There are three types of NED: pre-existing NED, therapy-induced NED and radiotherapy-induced NED. Pure neuroendocrine prostate cancer (NEPC) and a small cell PCa represent rare and aggressive tumors, such as primary carcinoids, which are also very rare. The most common clinical symptoms of small cell carcinoma are dysuria and urinary tract irritation. DRE, Trans-rectal ultrasound sonography, Abdomen scans, magnetic resonance imaging (MRI) scan and bone scintigraphy to know the prostate volume, its structure the presence or not of metastasis. In contrast to prostatic adenocarcinoma, PSA is an unreliable tumor marker for small cell prostate carcinoma and is usually normal, even when there is metastatic disease. The confirmation of SCC of the prostate relies mainly on pathological findings (morphological features and Immunohistochemical staining). The treatment for patients remains surgery and/or systemic chemotherapy but depends on the stage of the disease. We describe the case of a patient with small cell carcinoma of the prostate characterized by a normal PSA and a giant prostate volume.

Keywords: small cell carcinoma, giant prostate, PSA, chemotherapy.

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